ESCAPE is a mammalian embryonic stem cell specific database (Embryonic Stem Cell Atlas from Pluripotency Evidence). The database was created by collecting and integrating data reporting results from various published studies that profiled human and mouse ESCs including: protein-DNA binding interactions extracted from ChIP-seq/chip experiments, gene regulatory interactions from loss/gain-of-function studies followed by genome-wide mRNA expression profiling, protein interactions from immunoprecipitation followed by mass-spectrometry proteomics, a list of potential pluripotency regulators from RNA interference screens, ESC-specific proteins and phosphoproteins with specified phosphosites from proteomics and phosphoproteomics studies, time-course genome-wide mRNA microarray datasets from differentiating mouse ESCs, and histone modification status from genome-wide studies.
GATE is a software system used to analyze time-series expression data. It creates cluster files from time-series data for visualization as movies. It uses prior knowledge interaction networks and gene-lists libraries for identification of biological themes identified using the clustering analysis.
PMID: 20709693 | | EndNote Citation
Lists2Networks is a web-based software system used to analyze lists of mammalian genes. It creates a similarity matrix for many uploaded lists and compares the resultant lists to libraries of gene-lists from different categories. Users can create networks of lists and expand lists with prior knowledge networks such as protein-protein interactions, co-expression or co-annotation networks.
PMID: 20152038 | PMCID: PMC2843617 | EndNote Citation | Biositemaps (RDF)
Presynaptome: Network of protein-protein interactions within the synapse
Literature-based protein-protein interactions extracted from low-throughput experimental studies reporting interactions in mammalian presynaptic nerve terminals.
PMID: 19562802 | EndNote Citation | Biositemaps (RDF)
Literature-based cell signaling interactions extracted from literature describing components and interactions in mammalian neurons. This dataset was used in the paper (Ma'ayan et al. published in Science Aug. 12 2005).
PMID: 16099987 | EndNote Citation
Literature-based protein-protein interaction network extracted from publications describing functional interactions in adhesion complexes of mammalian cells. PMID: 17671451 | EndNote Citation | Biositemaps (RDF)
Literature-based protein-protein and gene-regulatory interactions extracted from publication describing interactions in mouse and human embryonic stem cells.
PMID: 19738627 | EndNote Citation | Biositemaps (RDF)
Kinase-substrate interactions collected from several databases collecting literature-based kinase-substrate interactions from experimental studies of mammalian cells.
PMID: 19176546 | EndNote Citation | Biositemaps (RDF)
Protein-protein interactions collected from several databases collecting literature-based protein-protein interactions from experimental studies of mammalian cells.
PMID: 17916244 | EndNote Citation | Biositemaps (RDF)
Files for download: A collection of Sig Files, and OWL Files (BioPAX2, BioPAX3) created from the Neuronal Signalome.
Six biological directed networks of different types and three man-made directed networks of different types used to the analysis of large directed cycles.
PMID: 19033453 | EndNote Citation
Neuro2A differentiation by Galphai/o pathway on Science Signaling
Cell signaling pathways that traces downstream signaling pathways from Gi/o-coupled GPCRs to key protein kinases and key transcription factors involved in neuronal differentiation. Components in the Science Signaling Connections Map are linked to Nature Molecule Pages.
PMID: 19155528 | EndNote Citation
A repository of models of signaling pathways. It includes reaction schemes, concentrations, rate constants, as well as annotations on the models. The database provides a range of search, navigation, and comparison functions.
PMID: 12584128 | EndNote Citation | Biositemaps (RDF)
Membrane Diffusion Coefficients
Partial Listing of diffusion coeffficients of integral membrane proteins provided by Suzanne Scarlata, PhD, SBCNY Investigator.