SBCNY - Systems Biology Center New York
Resources Spotlight
Drug Toxicity Signature Generation Center
The Drug Toxicity Signature Generation Center is a NIH-funded Systems Pharmacology research center at the Icahn School of Medicine. The proteomics experiments for the center are conducted at the Center for Advanced Proteomics, Rutgers-New Jersey Medical School. DToxS is part of the LINCS consortium of centers. LINCS (Library of Integrated Network-Based Cellular Signatures) is a program supported by the NIH Common Fund.
Many Experimental protocols for systems biology research are available here:
Research Highlights
Fragility of foot process morphology in kidney podocytes arises from chaotic spatial propagation of cytoskeletal instability.
Falkenberg CV, Azeloglu EU, Stothers M, Deerinck TJ, Chen Y, He JC, Ellisman MH, Hone JC, Loew LMIyengar R.
PLoS Comput Biol. 2017 Mar 16;13(3):e1005433
A biomimetic gelatin-based platform elicits a pro-differentiation effect on podocytes through mechanotransduction.
Hu M, Azeloglu EU, Ron A, Tran-Ba KH, Calizo RC, Tavassoly I, Bhattacharya S, Jayaraman G, Chen Y, Rabinovich V, Hone JC, He JC,4, Kaufman LJ.Iyengar R.
Sci Rep. 2017 Mar 6;7:43934.
Systems Pharmacology: An Overview
Marc R. Birtwistle, Jens Hansen, James M. Gallo, Sreeharish Muppirisetty, Peter Man-Un Ung, Ravi Iyengar and Avner Schlessinger
Systems Pharmacology and Pharmacodynamics Chapter 4 (02 December 2016)
Drug response consistency in CCLE and CGP.
Bouhaddou M, DiStefano MS, Riesel EA, Carrasco E, Holzapfel HY, Jones DC, Smith GR, Stern AD, Somani SS, Thompson TV, Birtwistle MR
Nature 2016 Nov 30;540(7631):E9-E10.
Cross-regulation of Phosphodiesterase 1 and Phosphodiesterase 2 Activities Controls Dopamine-mediated Striatal α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Trafficking.
Song RS, Tolentino R, Neves-Zaph SR Sobie EA
J Biol Chem. 2016 Oct 28;291(44):23257-23267.
Differential roles of two delayed rectifier potassium currents in regulation of ventricular action potential duration and arrhythmia susceptibility.
Devenyi RA, Ortega FA, Groenendaal W, Krogh-Madsen T, Christini DJ2, Sobie EA
J Physiol. 2016 Oct 24. doi: 10.1113/JP273191
Education, Resources & Tools
Gene Expression Data Analysis Tool - Enrichr
Enrichr is an integrative web-based and mobile gene-list enrichment analysis tool
Gene-list Enrichment Analysis Tool - CHEA
ChEA is a web-based system where users can input lists of mammalian gene symbols for which the program computes over-representation of transcription factor targets from the ChIP-X database.
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