This is a core course for entering PhD, MD/PhD and master’s students that introduces the student to integrated approaches to understanding physiological functions and the underlying biochemical, cell biological and molecular biological mechanisms. Elements of genetics and epidemiology are also included. For full description, download the Course Overview document. The emphasis is 'top-down', beginning with a patho-physiological condition studied from a clinical perspective going down to exploration of the biochemistry and molecular biology underlying the disease and normal state. The course uses a combination of experimental and computational approaches, including methodologies for handling large data sets and for generating different kinds of systems models. An Introductory Module introduces an array of basic concepts and computational tools that will be used throughout the four disease-focused modules that follow. Those four modules are focused on: Diabetes, Cancer, Renal Disease and Drug Abuse.