Systems Biomedicine: Molecules, Cells and Networks
BSR1800 - Systems Biology of Disease and Therapeutics (SDBT) Core Course

Course Director: Jeanne P. Hirsch
E-mail: jeanne.hirsch@mssm.edu
[Poster Fall 2012]

NameOverview of Systems Biomedicine: Molecules, Cells and Networks
Description

This is a core course for entering PhD, MD/PhD and master’s students that introduces the student to integrated approaches to understanding physiological functions and the underlying biochemical, cell biological and molecular biological mechanisms. Elements of genetics and epidemiology are also included. For full description, download the Course Overview document. The emphasis is 'top-down', beginning with a patho-physiological condition studied from a clinical perspective going down to exploration of the biochemistry and molecular biology underlying the disease and normal state. The course uses a combination of experimental and computational approaches, including methodologies for handling large data sets and for generating different kinds of systems models. An Introductory Module introduces an array of basic concepts and computational tools that will be used throughout the four disease-focused modules that follow. Those four modules are focused on: Diabetes, Cancer, Renal Disease and Drug Abuse.

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Course Overview
NameDiabetes Overview
DescriptionThe diabetes module consists of ten class sessions with faculty leaders. In addition, there are three or more TA sessions in which students can receive group or individualized help with computational or other problems. For full description, please download the Diabetes Module Overview document.

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Diabetes Module Overview
NameDiabetes Module Textbook Readings

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Textbook Readings
NameDiabetes Module Problem Sets

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Problem Set 1, Problem Set 2, Integration Problems
Name Of ClassOverview of Diabetes
LecturerDerek LeRoith, PhD
Professor
Medicine, Endocrinology
Diabetes and Bone Disease

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Class Lecture, Readings
Name Of ClassGlucose Metabolism
LecturerTerry A. Krulwich, PhD
Professor
Pharmacology and Systems Therapeutics

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Class Lecture, Assignments, Readings
Name Of ClassGlucose and Fatty Acid Metabolism and Oxidative Phosphorylation
LecturerTerry A. Krulwich, PhD
Professor
Pharmacology and Systems Therapeutics

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Class Lecture, Assignments, Readings
Name Of ClassInsulin Secretion
LecturerZ. Alex Ma, PhD
Associate Professor
Division of Experimental Diabetes and Aging

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Class Lecture, Readings
Name Of ClassThe Genetics of Diabetes
LecturerHelen C. Looker, MBBS
Assistant Professor
Medicine
Endocrinology
Diabetes and Bone Disease

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Class Lecture, Assignments, Readings
Name Of ClassRTK Signaling
LecturerDerek LeRoith, PhD
Professor
Medicine
Endocrinology
Diabetes and Bone Disease

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Class Lecture, Readings
Name Of ClassDiabetes Inflammation
LecturerAvrom J. Caplan, PhD
Professor,
Department of Biology
CCNY

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Class Lecture, Readings, Discussion Questions
Name Of ClassDrug Discovery
Lecturer Ross L. Cagan, PhD
Professor
Developmental and Regenerative Biology
Ophthalmology
Oncological Sciences

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Class Lecture, Readings, Journal Club Questions
Name Of ClassPathophysiology of Diabetes
LecturerChristoph Buettner, MD, PhD
Assistant Professor
Medicine
Endocrinology
Diabetes and Bone Disease
Neuroscience

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Class Lecture, Assignments, Readings
Name Of ClassDrug Strategies
LecturerDerek LeRoith, PhD
Professor
Medicine
Endocrinology
Diabetes and Bone Disease

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Class Lecture, Readings
NameOverview of Cancer Module
DescriptionThe cancer module consists of ten class sessions with faculty leaders and two scheduled TA sessions. TAs also participated in on-line Q&A in support document of work on problem sets. For full description, download Cancer Module Overview document.

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Cancer Module Overview
NameCancer Module Problem Sets

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Problem Set 1, Problem Set 2
Name Of ClassGrowth Control: Cell Cycle and Apoptosis
LecturerJeanne P. Hirsch, PhD
Associate Professor
Pharmacology and Systems Therapeutics
Oncological Sciences

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Lecture Outline, Class lecture
Name Of ClassMatLab: Modeling the Cell Cycle
LecturerEric A. Sobie, PhD
Assistant Professor
Pharmacology and Systems Therapeutics

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Class Lecture, Readings, dydt_tyson.m, tyson_ode.m
Name Of ClassSignaling Pathways in Cancer
Lecturer Ross L. Cagan, PhD
Professor
Developmental and Regenerative Biology
Ophthalmology
Oncological Sciences

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Class Lecture, Assignments
Name Of ClassUse of Model Organisms in Studying Cancer
LecturerCathie Pfleger, PhD
Assistant Professor
Oncological Sciences

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Class Lecture, Readings
Name Of ClassCancer Pathology
LecturerSimon J Hall, MD
Associate Professor & Chair Urology
Assistant Professor Gene and Cell Medicine

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Class Lecture
Name Of ClassCancer Genetics
LecturerJohn A. Martignetti, MD, PhD
Associate Professor
Genetics and Genomic Sciences
Oncological Sciences
Pediatrics

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Class Lecture
Name Of ClassCancer Biology Journal Club
LecturerStuart A. Aaronson, MD
Professor & Chair Oncological Sciences
Professor Medicine

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Class Lecture
ArticleDistinct types of diffuse large B-cell lymphoma identified by gene expression profiling.
Name Of ClassChemotherapeutics
LecturerHoward L. Kaufman, PhD
Department of Surgery and Oncological Sciences

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Class Lecture
Name Of ClassMetastasis
LecturerMihaela Skobe, PhD
Associate Professor
Oncological Sciences
Name Of ClassCancer Epidemiology
LecturerSusan Teitelbaum, PhD
Associate Professor
Preventive Medicine

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Class Lecture, Guidelines, Readings, Table

 

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