Network Statistics

Construction, Analysis and Visualization of a Large-scale Signaling Network in Hippocampal Neuronal Mammalian Cells

Source: Science. 2005 Aug;309(5737):1078-83.

Authors: Ma'ayan A, Jenkins SL, Neves S, Hasseldine A, Grace E, Dubin-Thaler B, Eungdamrong NJ, Weng G, Ram PT, Rice JJ, Kershenbaum A, Stolovitzky GA, Blitzer RD, Iyengar R.

Network Statistics

Number of components: 608
Number of interactions: 1427
Number of references: 1298

 

Types of Molecules

Total types of molecules: 43
Receptor: 53
Lipid: 7
Kinase: 89
Cyclase: 4
Ligand: 30
Cytoskeleton: 26
Adapter: 119
Synthase: 2
Vesicle: 21
Channel: 20
Ubiquitinase: 4
GTPase: 13
GAP: 15
GEF: 20
TF: 37
Bcl2Family: 8
Chaperone: 7
DNase: 1
Messenger: 8
Inhibitor: 20
Phosphatase: 19
Activator: 8
Protease: 8
Ion: 3
Matrix: 3
DNA: 4
Ribosome: 10
Elongation: 1
CellAdhesion: 7
Gprotein: 10
Transporter: 2
HDAC: 1
RNA: 2
Antagonist: 1
Peptide: 1
Polymerase: 1
PDE: 11
Pump: 2
Phospholipase: 4
Methylase: 1
Dismutase: 1
Sumo: 3
Hydrolase: 1

Types of Locations

Total types of locations: 9
Membrane: 82
Cytosol: 368
Extracellular: 34
Vesicles: 33
Nucleus: 48
Mitochondria: 9
ER: 13
Ribosomes: 21

Effects

Total types of effects: 3
+: 764
0: 311
_: 352

Types of Interactions

Total types of interactions: 19
Phosphorylation: 323
Binding: 888
Sumolation: 7
Ubiquitination: 11
Dephosphorylation: 66
Generating: 1
GEF: 29
GAP: 21
Deubiquitination: 1
Pumping: 2
Opening: 20
Cleavage: 34
Importing: 2
Synthesis: 9
PDE: 11
Depolymerization: 1
Methylation: 1

Connectivity Distribution

Links per Node Total Links In Links Out Links
1 146 167 223
2 109 86 84
3 100 37 60
4 56 25 29
5 47 19 7
6 43 15 7
7 18 10 3
8 10 7 2
9 11 6 3
10 11 4 2
11 6 4 1
12 8 1 2
13 6 2 0
14 3 1 1
15 8 1 1
16 3 0 2
17 2 0 1
18 2 0 0
19 3 0 2
20 2 1 0
21 1 0 0
22 2 0 0
23 1 0 0
24 0 0 0
25 2 0 0
26 0 0 0
27 1 0 0
28 0 0 0
29 1 0 0
30 1 1 0
31 0 0 0
32 2 0 2
33 0 0 0
34 0 0 0
35 0 0 0
36 0 0 0
37 0 0 0
38 2 0 0
39 0 0 2
40 0 0 0
41 0 0 0
42 2 0 0
43 0 0 0
44 0 0 0
45 0 0 0
46 0 0 2
47 0 0 0
48 0 0 0
49 0 0 0
50 2 0 0

Average links per node: 4.6875
Characteristic Path Length: 4.28937
Clustering Coefficient: 0.110581
Grid Coefficient: 0.0275154

Last updated:11/19/09