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G Proteins

Supplementary Figures

Molecular Basis for Interactions of G Protein bg Subunits with Effectors

Source: Science. 1998 May;280(5367):1271-4.

Effector Interactions with the b-Subunit of Heterotrimeric G Protein

Mutations that inhibit stimulation of adenylyl cyclase 2

Mutations that either enhance (dark color) or inhibit (light color) stimulation of beta-adrenergic receptor kinase

Mutations that either increase (dark color) or decrease (light color) inhibition of calcium channels

Mutations that inhibit stimulation of potassium channels

Mutations that either increase (dark color) or decrease (light color) stimulation of phospholipase C-beta 2

Residues important for Ga binding

Residues important for interactions with rhodopsin

Sidechains of Gb residues implicated in effector binding

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