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Systems Biology: Biomedical Modeling
G392 - Systems Biology of Disease and Therapeutics (SDBT) Core Course

Course Director: Eric Sobie
E-mail: eric.sobie@mssm.edu
In the News: Systems Biology Center Offers Computational Course, The Systems Biology Center New York Published Teaching Resources for their Systems Biology Course in Science Signaling

Abstract: Because of the complexity inherent in biological systems, many researchers frequently rely on a combination of global analysis and computational approaches to gain insight into both (i) how interacting components can produce complex system behaviors, and (ii) how changes in conditions may alter these behaviors. Because the biological details of a particular system are generally not taught along with the quantitative approaches that enable hypothesis generation and analysis of the system, we developed a course at Mount Sinai School of Medicine that introduces first-year graduate students to these computational principles and approaches. We anticipate that such approaches will apply throughout the biomedical sciences and that courses such as the one described here will become a core requirement of many graduate programs in the biological and biomedical sciences.

Teaching Resources Published In Science Signaling

Systems Biology--Biomedical Modeling
Eric A Sobie, Young-Seon Lee, Sherry L. Jenkins, and Ravi Iyengar
Abstract | Full Text | PDF

Introduction to Statistical Methods to Analyze Large Data Sets: Principal Components Analysis
Neil R. Clark and Avi Ma'ayan
Abstract | Full Text | PDF

Introduction to Statistical Methods for Analyzing Large Data Sets: Gene-Set Enrichment Analysis
Neil R. Clark and Avi Ma'ayan
Abstract | Full Text | PDF

Introduction to Network Analysis in Systems Biology
Avi Ma'ayan
Abstract | Full Text | PDF

An Introduction to Dynamical Systems
Eric A. Sobie
Abstract | Full Text | PDF

An Introduction to MATLAB
Eric A. Sobie
Abstract | Full Text | PDF

Obtaining and Estimating Kinetic Parameters from the Literature
Susana R. Neves
Abstract | Full Text | PDF

Biomedical Model Fitting and Error Analysis
Kevin D. Costa, Steven H. Kleinstein, and Uri Hershberg
Abstract | Full Text | PDF

Bistability in Biochemical Signaling Models
Eric A. Sobie
Abstract | Full Text | PDF

Computational Modeling of the Cell Cycle
Eric A. Sobie
Abstract | Full Text | PDF

Developing Models in Virtual Cell
Susana R. Neves
Abstract | Full Text | PDF

Simulations of Stochastic Biological Phenomena
Fernand Hayot
Abstract | Full Text | PDF

Probabilistic Reasoning in Data Analysis
Lawrence Sirovich
Abstract | Full Text | PDF

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